Prognostic factor research

Sample size guidance

  • Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond (PDF)

  • Evidence-Based Assessment and Application of Prognostic Markers: The Long Way from Single Studies to Meta-Analysis (PDF)

  • Prognostic Factors - Confusion caused by bad quality of design, analysis and reporting of many studies (PDF)

  • Prognostic Factor Studies (PDF)

Analysis guidance
  • Statistical aspects of prognostic factor studies in oncology (PDF)

  • Dangers of Using “Optimal” Cutpoints in the Evaluation of Prognostic Factors (PDF)

  • Dichotomizing continuous predictors in multiple regression: a bad idea (PDF)

  • The use of fractional polynomials to model continuous risk variables in epidemiology (PDF)